研究業績

原著論文

2024

1. Nagano K., Nakao T., Takeda M., Hirai H., Maekita H., Nakamura M., Imakawa N., Egawa A., Fujiwara T., Gao JQ., Kinoshita K., Sakata M., Nishino M., Yamashita T., Yoshida T., Harada K., Tachibana K., Doi T., Hirata K., Tsujino H., Higashisaka K., Tsutsumi Y. : Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin., Food Chemistry, 437, 137866, 2024.[IF=8.8]

2023

1. Yamashita T., Tsutsumi R., Nagano K. : Extracellular vesicles derived from the serum of Seriola quinqueradiata induce human umbilical vein endothelial cell proliferation through angiogenic signaling., Biol. Pharm. Bull., 46(11), 1643-1646, 2023. 

2022

1. Nagano K., Maekita H., Hirai H., Nakao T., Kinoshita K., Sakata M., Nishino M., Tsujino H., Higashisaka K., Tsutsumi Y. : Activity of curcumin depends on initial dispersion solvent., Jpn. J. Food Chem. Safety, 29(3), 179-183, 2022.
2. Muraoka M., Ohno M., Nakai T., Matsuura H., Nagano K., Arai M., Hirata Y., Uyama H., Hirata K. : Gamma-glutamylcysteine production using phytochlatin synthase-like enzyme derived from Nostoc sp. Covalently immobilized on a cellulose carrier., Biol. Pharm. Bull., 45(8), 1191-1197, 2022.
3. Eto S., Higashisaka K., Koshida A., Sato K., Ogura M., Sakurai M., Tsujino H., Nagano K., Tsutsumi Y. : Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity., Nano Express., 3(1), 2022.
4. Higashisaka K., Takeya S., Kamada H., Obana M., Maeda M., Kabayama M., Yamamoto K., Ishida N., Isaka R., Tsujino H., Nagano K., Tomiyama N., Rakugi H., Fujio Y., Kamide K., Tsutsumi Y. : Identification of biomarkers of chronic kidney disease among kidney-derived proteins., Clinical Proteomics., 19(3), 2022.
5. Nakajima T¹., Nagano K.¹*, Fukuda Y¹., Ishima Y., Shibata H., Isaka R., Zhang T., Haga Y., Higashisaka K., Tsujino H., Ishida T., Ishii-Watabe A. , Tsutsumi Y*. : Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice., Journal of Pharmaceutical Sciences., 19(1), 3, 2022.
   (1 : equal contributor, * : corresponding author)
6. Yang L., Shimoda M., Haga Y., Sekine N., Tsujino H., Nagano K., Shimazu K., Tsutsumi Y. : Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR., Biochem. Biophys. Res. Commun., 588, 175-181, 2022.
7. Eto S., Koshida A., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y.：Silica particles with human protein corona shows sensitization potential in the human cell line activation test., BPB Reports., 5(1), 1-4, 2022.
8. Muraoka M., Yoshida S., Ohno M., Matsuura H., Nagano K., Hirata Y., Arai M., Hirata K. : Reactivity of γ-glutamyl-cysteine with intracellular and extracellular glutathione metabolic enzymes., FEBS Letter., 596(2), 180-188, 2022.
9. Yang L., Higashisaka K., Haga Y., Tsujino H., Nagano K., Tsutsumi Y. : Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells promote endothelial cell tube formation through activating mTOR., Pharmazie, 77(2), 45-47, 2022.

2021

1. Isaka R., Ishida N., Kitahara G., Sakahashi Y., Haga Y., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y. ： Indoxyl sulfate induces an inflammatory response in the proximal tubule via macrophages., BPB Reports., 4(6), 198-201, 2021.
2. Hanamuro S., Lin Y., Konishi H., Izusawa K., Yang L., Haga Y., Tsujino H., Nagano K., Higashisaka K., Tsutsumi Y. : Progesterone receptor membrane component 2 expression leads to erlotinib resistance in lung adenocarcinoma cells., Pharmazie, 76(12), 602-605(4), 2021.
3. Muraoka M., Ohno M., Tateishi M., Matsuura H., Nagano K., Hirata Y., Hirata K. : Optimization of reaction conditions for γ-glutamylcysteine production from glutathione using a phytochelatin synthase-like enzyme from Nostoc sp. Pasteur Culture Collection 7120., Biol. Pharm. Bull., 44(12), 1832-1836, 2021.
4. Okajima C¹., Imakawa N¹., Nagano K¹*., Arai M., Arisawa M., Muraoka M., Tsujino H., Hirata Y., Hirata K*. : Inhibitory activity and proposed binding model of γ-glutamyl cysteine, the precursor of glutathione, on angiotensin converting enzyme., BPB reports., 4(4), 116-119, 2021.
   (1 : equal contributor, * : corresponding author)
5. Ogawa T., Okumura R., Nagano K., Minemura T., Izumi M., Motooka D., Nakamura S., Iida T., Maeda Y., Kumanogoh A., Tsutsumi Y., Takeda K. : Oral intake of silica nanoparticles exacerbates intestinal inflammation., Biochem. Biophys. Res. Commun., 534: 540-546, 2021.

総説論文

2023

1. Higashisaka K., Yamashita T.：Evaluation of Health Impact and Risk Analysis of Chemical Substances., Yakugaku Zasshi, 143(2), 1-2, 2023.